Taking multiple medicines safely: MedlinePlus Medical Encyclopedia (2024)

If you take more than one medicine, it is important to take them carefully and safely. Some medicines can interact and cause side effects. It can also be hard to keep track of when and how to take each medicine.

Here are tips to help you keep track of your medicines and take them as directed.

Why you may Need More Than one Medicine

You may take more than one medicine to treat a single condition. You may also take different medicines to treat more than one health problem. For example, you may take a statin to lower your cholesterol, and a beta-blocker to control your blood pressure.

Older adults often have more than one health condition. So they are more likely to take several medicines.

Risks of Taking Multiple Medicines

The more medicines you take, the more you need to use them carefully. There are several risks when taking multiple medicines.

  • You may be more likely to have side effects. Because most medicines can have side effects, the more medicines you take, the more likely you will have side effects. Taking certain medicines can also increase the risk for falls.
  • You are at higher risk for drug interactions. An interaction is when one medicine affects how another medicine works. For example, taken together, one medicine may make the other medicine stronger. Medicines can also interact with alcohol and even some foods. Some interactions can be serious, even life threatening.
  • You may find it hard to keep track of when to take each medicine. You even may forget which medicine you have taken at a certain time.
  • You may take a medicine you do not need. This may be more likely to happen if you see more than one health care provider. You may be prescribed different medicines for the same problem.

People at Higher Risk

Certain people are more likely to have problems from taking multiple medicines:

  • People who are prescribed 5 or more medicines. The more medicines you take, the higher the chance of interactions or side effects. You may also find it hard to remember all possible drug interactions.
  • People who take medicines prescribed by more than one provider. One provider may not know that you are taking medicines another provider has given you.
  • Older adults. As you age, your body processes medicines differently. For instance, your kidneys may not work as well as they used to. This can mean that more medicine stays in your body for longer. This can lead to dangerous levels of medicines in your system.
  • People in the hospital. When you are in the hospital, you will likely see new providers who are not familiar with your health history. Without this knowledge, they may prescribe a medicine that may interact with medicines you already take.

What you can do

These suggestions can help you take all of your medicines safely:

  • Keep a list of all medicines you take. Your list should include all prescription and over-the-counter (OTC) medicines. OTC medicines include vitamins, supplements, and herbal products. Keep a copy of the list in your wallet and at home.
  • Review your medicine list with your providers and pharmacists. Discuss the list with your provider each time you have an appointment. Ask your provider if you still need to take all of the medicines on your list. Also ask if any of the dosages should be changed. Make sure you give all of your providers a copy of your medicine list.
  • Ask questions about any new drugs you are prescribed. Make sure you understand how to take them. Also ask if a new medicine could interact with any of the medicines or supplements you are already taking.
  • Take your medicines exactly as your provider tells you. If you have questions about how or why to take your medicine, ask your provider. Do not skip doses, or stop taking your medicines.
  • If you notice side effects, tell your provider. Do not stop taking your medicines unless your provider tells you to.
  • Keep your medicines organized. There are many ways to keep track of your medicines. A pill organizer may help. Try one or more methods and see what works for you.
  • If you have a hospital stay, bring your medicine list with you. Talk with your provider about medicine safety while you are in the hospital.

Call if you have questions or you are confused about the directions for your medicine. Call if you have any side effects from your medicines. Do not stop taking any medicine unless your provider tells you to stop.

Alternative Names

Polypharmacy

References

Agency for Healthcare Research and Quality website. 20 tips to help prevent medical errors: patient fact sheet. www.ahrq.gov/patients-consumers/care-planning/errors/20tips/index.html. Updated November 2020. Accessed August 11, 2022.

National Institute on Aging website. www.nia.nih.gov/health/safe-use-medicines-older-adults. Updated June 26, 2019. Accessed August 11, 2022.

Ryan R, Santesso N, Lowe D, et al. Interventions to improve safe and effective medicines use by consumers: an overview of systematic reviews. Cochrane Database Syst Rev. 2014;29(4):CD007768. PMID: 24777444 pubmed.ncbi.nlm.nih.gov/24777444/.

US Food & Drug Administration website. Buying & using medicine safely. www.fda.gov/drugs/information-consumers-and-patients-drugs/buying-using-medicine-safely. Updated April 9, 2024. Accessed April 22, 2024.

US Department of Health and Human Services website. Healthy living: use medicines safely: the basics. health.gov/myhealthfinder/healthy-living/safety/use-medicines-safely#the-basics-tab. Updated July 20, 2022. Accessed August 11, 2022.

US Department of Health and Human Services website. Healthy living: use medicines safely: take action. health.gov/myhealthfinder/healthy-living/safety/use-medicines-safely#take-action-tab. Updated July 20, 2022. Accessed August 11, 2022.

Review Date 8/11/2022

Updated by: Linda J. Vorvick, MD, Clinical Professor, Department of Family Medicine, UW Medicine, School of Medicine, University of Washington, Seattle, WA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

Related MedlinePlus Health Topics

  • Drug Reactions

Browse the Encyclopedia

Taking multiple medicines safely: MedlinePlus Medical Encyclopedia (2024)

FAQs

Is it safe to take multiple medications at once? ›

Risks of Taking Multiple Medicines

You may be more likely to have side effects. Because most medicines can have side effects, the more medicines you take, the more likely you will have side effects. Taking certain medicines can also increase the risk for falls. You are at higher risk for drug interactions.

Is it better to take more of one medicine or multiple medicines? ›

Active ingredients in medicines can 'clash'. So, taking more than one medicine at the same time can increase the risk of side effects. Tell your doctor about all the medicines you are taking. You may like to have an annual review of all your medications.

What medications should never be taken together? ›

What Are the 7 More Dangerous Medicines to Mix?
  • Alcohol and opioids.
  • Opioids and benzodiazepines.
  • Warfarin and acetaminophen.
  • Warfarin and ibuprofen.
  • PDE-5 inhibitors and nitrates.
  • Statins and amiodarone.
  • ACE inhibitors and potassium supplements.

How long should you wait between taking different medications? ›

Your pharmacist will put a sticker on the your bottle to warn you of this interaction. To avoid the interaction you may need to space the timing of your doses, taking each drug 2 hours before or 4 hours after the other drug.

How much gap should there be between two medicines? ›

Taking your medications at the proper intervals during the day. Try to divide up your dosing times as evenly as possible throughout the day: for example, every 12 hours for a drug that needs to be taken twice a day, or every 8 hours for a drug that needs to be taken three times a day.

How many medications are too many? ›

However, taking too many prescription medications can be risky. Taking more than five medications is called polypharmacy. The risk of harmful effects, drug interactions and hospitalizations increase when you take more medications.

What are the risks of multiple medications? ›

Multiple medications can cause confusion, lightheadedness and even internal bleeding — all dangerous and injurious conditions.

Can taking too many pills damage your liver? ›

Large doses of many medicines can damage a normal liver. Many different drugs can cause drug-induced hepatitis. Painkillers and fever reducers that contain acetaminophen are a common cause of liver injury, particularly when taken in doses greater than those recommended.

What prescription drugs have the worst side effects? ›

A number of psychiatric medications such as olanzapine (Zyprexa), quetiapine (Seroquel), and haloperidol (Haldol) have all been associated with causing hallucinations, in addition to zolpidem (Ambien), eszopiclone (Lunesta), clonazepam (Klonopin), lorazepam (Ativan), ropinirole (Requip), and some seizure medications.

What are 5 drugs to avoid in the elderly? ›

  • factors3 Melatonin4. Cardiovascular. ...
  • blockers. Rhythm control5 dofetilide (Tikosyn), ...
  • (Rhythmol) Heart failure6 beta blocker, ACEIb, ARBc, ...
  • Nifedipine extended release (Procardia XL)7. Depression. ...
  • comparable to placebo. ...
  • venlafaxine, duloxetine, buspirone (Buspar) ...
  • pregabalin (Lyrica) ...
  • (Topamax)

What medications can cause sudden cardiac death? ›

Follow us:
Drug familyKnown risk
Cholinesterase inhibitorsDonepezil
Antihistamines
Non-sedating or 2nd generationTerfenadine, astemizole
OpiatesMethadone
41 more rows

What medications should not be taken with SAMe? ›

Possible interactions include:
  • Antidepressants and other drugs and supplements that increase levels of serotonin. Don't take SAMe with antidepressants. ...
  • Antipsychotics. Be cautious when taking these drugs with SAMe. ...
  • Amphetamines. Be cautious when taking these drugs with SAMe. ...
  • Dextromethorphan. ...
  • Levodopa. ...
  • Narcotics. ...
  • St.

How should I take multiple medications? ›

Use a medication manager

Some people opt for traditional pill boxes, which have different compartments for each day of the week, and even compartments for different times of the day. If you use this kind of system, make sure to put reminders on your phone that will alert you when it's time to take a medication.

Is it okay to take three medicines at the same time? ›

This is when two or more drugs taken at the same time or in the same period don't mix well and cause unintended health problems. These interactions can make medications less effective and cause unexpected side effects, such as drowsiness, dizziness, constipation, nausea, heart palpitations, rash and stomach irritation.

How do you know if you are taking too much medication? ›

Symptoms of a drug overdose (including alcohol poisoning) may include: nausea and vomiting. severe stomach pain and abdominal cramps. diarrhoea.

Can you take two different prescriptions at the same time? ›

There are many types of drugs you shouldn't take together, but in general, don't take combinations like these: Two or more drugs that share an active ingredient. You could have side effects or an overdose. Active ingredients are the chemicals in medications that treat your condition or symptoms.

Can you take two different drugs at the same time? ›

So, all drugs have risks, but I would say that mixing and matching is one of the worst things one can do as it can produce unintended, even fatal effects. So, it's important for people to know that taking drugs in combination can be far more dangerous than taking each of those substances by themselves.

What are the symptoms of overmedication? ›

Potential signs include: drowsiness; physical complications, like dry mouth and ulcers; confusion; withdrawal from family or friends; hallucinations; dizziness or falls; fractures; and seizures. If your loved one experiences these warning signs or any sudden changes in behavior, notify a doctor immediately.

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