Mebendazole vs Metronidazole Comparison - Drugs.com (2024)

FAQs

Mebendazole vs Metronidazole Comparison - Drugs.com? ›

Comparing Mebendazole vs Metronidazole

We have concluded that mebendazole is inferior to metronidazole and furazolidone, although it is given at 200 mg three times daily for 10 days in the treatment of giardiasis infection of children, but for clarification of the argument, we need more extensive and comparative studies.

Mebendazole (Vermox) is used to treat roundworm and whipworm infections. Mebendazole (Emverm) is used to treat pinworm, whipworm, roundworm, and hookworm infections.

Why is Mebendazole discontinued? Mebendazole was discontinued in 2011 due to the poor tissue penetration of Mebendazole and the current availability of albendazole and not for safety or efficacy reasons, stated by the Federal Register determination.

Both agents were equally very effective (100% cure rate) in treating ascariasis. Albendazole was clearly more active than mebendazole against hookworm infections, both in terms of egg reduction rate (92.8% vs. 62.4%) and cure rate (81.8% vs. 17.2%).

Tinidazole has the potential of being a more efficacious drug for BV based on its longer half-life and its seemingly superior side effect profile as compared to oral metronidazole.

Metronidazole is one of the mainstay drugs for the treatment of anaerobic bacterial infections, protozoal infections, and microaerophilic bacterial infections. It is cytotoxic to facultative anaerobic microorganisms.

Garlic supplements

A 2014 study found that garlic supplement tablets had a similar therapeutic effect in treating BV as metronidazole, an oral antibiotic. However, it is important to note that the above study assessed oral garlic supplements only.

You'll usually take mebendazole as a single dose to treat threadworms, but you might need to take it for around 3 days for some other types of worm infection.

Who should not take mebendazole? ›

Mebendazole is not suitable for some people. To make sure it's safe for you, tell a pharmacist or doctor if you: have ever had an allergic reaction to mebendazole or any other medicine. are pregnant or breastfeeding.

Albendazole and mebendazole are most frequently prescribed for treatment of intestinal nematode infections (ascariasis, hookworm infections, trichuriasis, strongyloidiasis, and enterobiasis) and can also be used for intestinal tapeworm infections (taeniases and hymenolepiasis).

This medicine may cause serious skin reactions when taken together with metronidazole. Check with your doctor right away if you have blistering, peeling, or loose skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin, or fever or chills while you are using this medicine.

There have been rare reports of acute liver injury due to mebenazole, particularly when it is given repeatedly or in higher doses. The onset is usually with fever and malaise within days of starting or restarting therapy. The pattern of serum enzyme elevations is typically hepatocellular, and jaundice is uncommon.

Drink a lot of water to help flush out your system. Eat more fiber, which may help get rid of worms. Probiotics ( Lactobacillus acidophilus, Lactobacilus plantarum, Saccharomyces boulardii, and bifidobacteria ). Help keep your digestive tract healthy.

Combination therapy involving metronidazole and mebendazole should therefore be avoided because of the increased risk of developing Stevens–Johnson syndrome or toxic epidermal necrolysis.

Results showed that albendazole was as effective as metronidazole for the treatment of giardiasis in humans and people receiving the drug tended to have fewer side effects compared with those who received metronidazole.

Metronidazole Brand names: Acea, Anabact, Flagyl, Metrogel, Metrosa, Rosiced, Rozex, Vaginyl, Zidoval, Zyomet. Find out how metronidazole treats infections and how to take it.

Management and Treatment

Common parasitic drugs include: Pyrantel pamoate for pinworms. Mebendazole or albendazole for soil-transmitted intestinal worms. Metronidazole, tinidazole or trimethoprim/sulfamethoxazole (TMP-SMX) for protozoa infections.